Medical Pharmacology: Drug Metabolism Practice Questions

Medical Pharmacology: Drug Metabolism Practice Questions

Choose the correct answer for each question.

Flavin containing monooxygenases (FMOs):
1. Phase II enzyme system
2. High levels found in the liver
3. Associated with the endoplasmic reticulum.
4. A & B
5. B & C
6. A & C
7. A, B & C
Example/example of histamine-2 receptor blocker(s) metabolized by flavin-containing monooxygenases (FMOs):
1. Ranitidine
2. Clozapine
3. Cimetidine
4. A & B
5. B & C
6. A & C
7. A, B & C
Flavin-containing monooxygenases:
1. Comparable to cytochrome P450 systems in the extent of contribution to drug metabolism.
2. Often produce toxic metabolites.
3. Both
4. Neither
Flavin-containing monooxygenases (FMOs) are not typically involved in drug-drug interactions.
1. True
2. False
Comparing itopride, an antiemetic, metabolized by FMO3, one of the six families of FMOs) with cisapride, also used in management of gastric motility, but metabolized by CYP3A4: Which one of these two agents is more likely to exhibit drug-drug interactions?
1. Cisapride
2. Itopride
Mechanism/mechanisms by which CYP3A4 might participate in drug-drug interactions:
1. Inhibition of metabolism
2. Induction of metabolism
3. Both
4. Neither
Microsomal epoxide hydrolase (mEH) is involved in the inactivation of the active carbamazapine metabolite.
1. True
2. False
Epoxide hydrolases:
1. Epoxide substrates are often produced by cytochrome P450 enzymes.
2. Epoxide hydrolase may be localized in cytosol or endoplasmic reticular membranes.
3. Both
4. Neither
Soluble epoxide hydrolases (sEH) inhibitors:
1. Appear to decrease both inflammatory and neuropathic pain.
2. May work synergistically with nonsteroidal anti-inflammatory agents.
3. Both
4. Neither
Valproate, antiepileptic agent, inhibits mEH and is therefore associated with clinically relevant drug interactions with another anticonvulsant drug, carbamazapine.
1. True
2. False

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Source Material:
- Buxton ILO Chapter 2: Pharmcokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimiation in Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14e, (Brunton LL H Knollmann BC, eds) McGraw-Hill Education, 2023.
- Gonzalez FJ Coughtrie M Chapter 5: Drug Metabolism in Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14e, (Brunton LL H Knollmann BC, eds) McGraw-Hill Education, 2023.
- Holford NHG Chapter 3: Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action: in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah TW, Associate editor) 15e McGraw Hill 2021.
- Correia MA Chapter 4 Drug Biotransformation in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah TW, Associate editor) 15e McGraw Hill 2021.
- Baca QJ Golan DE Pharmacokinetics Chapter 3: Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. (Golan DE, editor-in chief, Armstrong EJ Armstrong AW, associate editors) 4e Wolters Kluwer 2017.
- Guengerich FP Chapter 4: Drug Metabolism in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. (Golan DE, editor-in chief, Armstrong EJ Armstrong AW, associate editors) 4e Wolters Kluwer 2017.
- Flood P Shafer SL Chapter 2 Basic Principles of Pharmacology in Stoelting's Pharmacology & Physiology in Anesthetic Practice (Glood P Rathmell JP Urman RD, eds) 6e Wolters Kluwer 2022.
- Burchum JR Rosenthal LD Lehne's Pharmacology for Nursing Care Unit II Chapter 4 Pharmcokinetics 11 e Elsevier 2022.