Question # 1 (Multiple Answer) CNS serotonin:

A) mood
B) sleep
C) appetite
D) pain perception
E) vomiting

Question # 2 (True/False) Propofol (Diprivan) for induction and maintenance of anesthesia may be as effective as ondansetron (Zofran) in reducing/preventing postoperative emesis

A) true
B) false

Question # 3 (Multiple Choice) Serotonin overproduction (carcinoid tumor):

A) constipation
B) diarrhea

Question # 4 (Multiple Choice) Major clinical use(s): cyproheptadine (Periactin):

A) reduces smooth muscle effects of carcinoid tumor
B) reduces postgastrectomy dumping syndrome
C) both
D) neither

Question # 5 (Multiple Choice) Widely distributed indoleethylamine formed from tryptophan:

A) epinephrine
B) nicotine
C) serotonin
D) leukotriene
E) prostaglandins

Question # 6 (True/False) Serotonin -- gastrointestinal tract effects:decreased peristalsis

A) true
B) false

Question # 7 (Multiple Choice) Antiemetic agent with least side effects

A) chlorpromazine (Thorazine)
B) butyrophenones
C) ondansetron (Zofran)
D) diphenhydramine (Benadryl)

Question # 8 (Multiple Choice) Serotonin: platelet effects --

A) promotes aggregation
B) inhibits aggregation

Question # 9 (Multiple Choice) Greater than 90% of serotonin is located here:

A) platelets
B) raphe nucleus (brain stem)
C) enterochromaffin cells of the GI tract
D) lung
E) cerebral cortex

Question # 10 (Multiple Answer) Cardiovascular effects of serotonin:

A) skeletal muscle vasculature: vasodilatation
B) reflex bradycardia
C) pulmonary and renal vasculature: vasoconstriction

Question # 11 (Multiple Answer) Sumatriptan (Imitrex) and migraine:

A) relieves symptoms for few patients
B) efficacy greater than or equal to other drug treatments
C) multiple dosing may be required

Question # 12 (Multiple Answer) Serotonin agonists -- clinical use:

A) buspirone -- anxiolytic
B) sumatriptan (Imitrex) -- antimigraine; anti-cluster headaches
C) both
D) neither

Question # 13 (Multiple Answer) Serotonin: nervous system --

A) stimulates itch and pain sensory nerve endings
B) activates chemosensitive nerve endings in coronary vessels
C) atropine-sensitive bradycardia
D) activates medullary vomiting reflex (5 HT3)

Question # 14 (Multiple Choice) ondansetron (Zofran), granisetron (Kytril), tropisetron interact with its serotonin receptor subtype located in the area postrema, sensory, and enteric nerves:

A) 5 HT1a
B) 5 HT1d
C) 5 HT3
D) 5 HT4

Question # 15 (Multiple Choice) Sumatriptan (Imitrex) -- contraindications

A) presence of ischemic heart disease
B) patients have variant (Prinzmetal's) angina
C) both
D) neither

Question # 16 (Multiple Answer) Ondansetron (Zofran) -- pharmacology:

A) activates dopamine (Intropin), histamine and adrenergic receptors
B) very effective for prevention of nausea iand vomiting caused by chemotherapy or surgery
C) reduces postoperative vomiting in patients following middle ear surgery

Question # 17 (Multiple Answer) Adverse effects -- sumatriptan (Imitrex)

A) muscle weakness
B) chest pain
C) dizziness
D) altered sensations (tingling, warmth recurrent