Medical Pharmacology Practice Questions: Histamine Pharmacology

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Which one(s) of the following statements concerning histamine is/are correct?
1. Histamine is involved in neurotransmission in some systems.
2. Histamine is a major inflammatory mediator..
3. Histamine is involved in gastric acid secretion.
4. Histamine plays an important role in anaphylaxis.
5. A & B
6. B & C
7. A & C
8. A, B, C & D
Concerning histamine receptors:
1. Histamine antagonists specific for particular histamine receptor subtypes have been developed.
2. Four receptors for histamine have been cloned.
3. Both
4. Neither
Competitive blockers at H1 (histamine receptors type 1) effectively reduce gastric acid secretion.
1. True
2. False
Therapeutic uses of H1 receptor competitive blockers include/includes:
1. Motion sickness
2. Urticaria
3. Insomnia
4. A & B
5. B & C
6. A & C
7. A, B & C
Bradykinin exhibits cardiovascular effects considered similar to those provoked by histamine.
1. True
2. False
This/these histamine receptor subtypes have resulted in new antagonist drugs.
1. H1
2. H2
3. H3
4. H4
5. A & B
6. A & C
7. B & C
8. A, B & C
This histamine receptor subtype is expressed in hemopoietic related cells.
1. H1
2. H2
3. H3
4. H4
The mass cell represents the major storage site in most tissues for histamine.
1. True
2. False
Histamine concentrations in human CSF (cerebrospinal fluid), plasma, and other bodily fluids are typically very low.
1. True
2. False
Enzyme responsible for histamine synthesis:
1. Histidine transaminase
2. Histidine decarboxylase
3. Histidine kinase
4. Histidine aminotransferase