Medical Pharmacology Practice Questsions: Anti-Histamine Pharmacology

H1 histamine receptor blockers inhibit which one(s) of the following histamine-induced exocrine secretions?
1. Lacrimal secretions
2. Gastric secretion
3. Salivary secretions
4. A & C
5. B & C
6. A & B
7. A, B & C
Associated with hypersensitivity reactions histamine represents one of numerous significant autocoids released. Of various effects associated with hypersensitivity, which one(s) of the following effects are well suppressed?
1. Itch
2. Edema formation
3. Both
4. Neither
CNS stimulation,in effect associated with overdose of first-generation H1 histamine receptor blockers, may result in convulsions, notably in infants.
1. True
2. False
Newer, second-generation "nonsedating" antihistamine H1 receptor blockers are associated with limited sedation despite crossing the blood brain barrier readily.
1. True
2. False
Many antipsychotic drugs are blockers at which one(s) of the following receptor types?
1. H1 receptors
2. H2 receptors
3. Both
4. Neither
Blockade of this histamine receptor subtype is associated with weight gain following administration of atypical and typical antipsychotic drugs.
1. H1
2. H2
3. Neither
The most effective H1-histamine receptor blocker for managing motion sickness:
1. Loratadine
2. Pyrilamine
3. Chlorcyclizine
4. Promethazine
H1 histamine receptor blockers, following oral administration, exhibit peak plasma concentrations in this timeframe:
1. <1 hour
2. 2-3 hours
3. 7-8 hours
4. About 12 hours
Which one(s) of the following statements concerning H1 antagonist metabolism is/are correct?
1. H1 antagonists are eliminated more rapidly in adults compared to children.
2. H1 antagonists are illuminated readily even in patients with significant liver disease.
3. H1-receptor blockers can induce hepatic cytochrome P450 isoforms.
4. A & B
5. B & C
6. A & C
7. A, B & C
Loratadine is a prodrug because it must be undergoes hepatic metabolism, cytochrome P450-mediated, to an active metabolite.
1. True
2. False