Medical Pharmacology: Immunopharmacology Practice Questions
Glucocorticoids I
Steroidogenesis
Attribution: David Richfield (Slashme)
and Mikael Häggström. Derived from previous version by Hoffmeier
and Settersr.In external use, this diagram may be cited as:
(2014). "Diagram of the pathways of human steroidogenesis".
WikiJournal of Medicine 1 (1). DOI:10.15347/wjm/2014.005. ISSN
20018762., CC0, via Wikimedia Commons
First hormonal drugs noted to have "lympholytic" characteristics.
Glucocorticoids administration decreases lymphoid content at lymph nodes and spleen without toxic effects on proliferating bone marrow erythroid stem cells.
Both
Neither
Glucocorticoids:
Immunological effects are likely associated with modification of cell functions as opposed to direct cytotoxicity.
Glucocorticoids administration is more likely to influence cellular immunity compared to hormonal immunity.
Both
Neither
Chronic glucocorticoid administration results in the decrease of specific antibodies.
True
False
Glucocorticoids exhibit both anti-inflammatory and immunosuppressive properties.
True
False
Immunosuppressive and anti-inflammatory characteristics of glucocorticoids are likely central to positive clinical results in which one(s) of the following diseases?
Rheumatoid arthritis
Thrombocytopenic purpura
Both
Neither
Prednisone administration is likely to be effective in this/these autoimmune disease(s):
Acute glomerulonephritis
Autoimmune hemolytic anemia
Both
Neither
Glucocorticoids:
Bind to intracellular receptors
Regulate gene transcription
Both
Neither
Glucocorticoids administration:
Reduces activation of nuclear factor-κB
Reduces proinflammatory cytokine formation (e.g. IL-1 and IL6)
Both
Neither
Glucocorticoids:
Reduce IL-2 synthesis by T cells and reduced T-cell proliferation
Inhibit cytotoxic T-lymphocyte activation
Both
Neither
Glucocorticoids administration in excess may likely induce "disabling" and "life-threatening" adverse consequences.
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Source Material:
Rothlin C Gutkind J Chapter 39
Immunosuppressants, Immunomodulation and Tolerance In
Goodman & Gilman's The Pharmacological Basis of Therapeutics
(Brunton LL Knollman BC eds) McGraw Hill LLC (2023).
Lake D & Briggs A Ch 55 Immunopharmacology
in Katzung's Basic & Clinical Pharmacology (Vanderah TW, ed)
16e McGraw Hill 2023.
Brezinski E Klickstein L Armstrong A Ch 46
Pharmacology of Immunosuppression in Principles of
Pharmacology: The Pathophysiologic Basis of Drug Therapy.
(Golan DE Armstrong EJ Armstrong AW, eds) 4e 2017 ls) 4e
2017
Ritter JM Flower R Henderson G Loke YK
MacEwan D Robinson E Fullerton J Ch 54 Anti-inflammatory and
Immunosuppressant Drugs Rang & Dale's Pharmacology 10e
Elsevier 2024.
Bass A Rogatsky Ch 32 Immunomoduolatory Drugs
in Goldman-Cecil Medicine (Goldman L Schafer, eds) Elsevier
26e 2020
Leiva M Takemoto Ch 238 Immunosuppressants in
Lippincott Illustrated Reviews: Pharmacology 8e ((Walen et
al, eds) Wolters Kluwer 2023
