Medical Pharmacology: Immunopharmacology Practice Questions

Glucocorticoids:
1. Effects of glucocorticoids involves binding to intracellular glucocorticoid receptors.
2. Glucocorticoid receptors represent one member of the superfamily of nuclear receptors.
3. Both
4. Neither
Glucocorticoid mechanism of action:
1. Unless the hormonal ligand is present, glucocorticoid receptors are mainly cytoplasmic.
2. Cytoplasmic glucocorticoid receptors exists in oligomeric complexes (usually proteins group together) with heat-shock proteins (Hsp).
3. Both
4. Neither
Heat shock proteins complexed with glucocorticoid receptors, usually additionally include two molecules of Hsp90.
1. True
2. False
Glucocorticoid receptors and free hormone:
1. If free hormone is present in the cell, the hormone will bind to the glucocorticoid receptor.
2. Hormone-glucocorticoid receptor combination promotes dissociation of the receptor from previously bound heat shock proteins.
3. Both
4. Neither
Dimeric hormone-bound glucocorticoid receptor complex, following translocation to the nucleus, interacts with both DNA and nuclear proteins.
1. True
2. False
Glucocorticoid effect(s):
1. Suppress activation in function of innate as well as adaptive cells of the immune system.
2. Down-regulation of numerous inflammatory mediators.
3. Both
4. Neither
Consequence/consequences of extended glucocorticoid administration (adverse effects/effects):
1. Diabetes
2. Susceptibility to infection
3. Both
4. Neither
Non-tapered, abrupt termination of glucocorticoid administration may induce acute adrenal-insufficiency.
1. True
2. False
The main reason that glucocorticoid administration induce immunosuppression is their limiting clonal proliferation of Th cells.
1. True
2. False
Glucocorticoid-mediated decrease in Th cell clonal proliferation occurs by reduction of IL2 gene transcription.
1. True
2. False

Glucocorticoids: Mechanisms and Side Effects

Attribution: Farina D "Professor Dave Explains" Glucocorticoid: Mechanisms and Side Effects 2022 (11.44 min) https://www.youtube.com/watch?v=F2COZ97gCVo Professor Dave Explains youtube site: https://www.youtube.com/@ProfessorDaveExplains

Glucocorticoids: Mechanisms and Side Effects

Attribution:
- Farina D "Professor Dave Explains" Glucocorticoid: Mechanisms and Side Effects 2022 (11.44 min)
  - https://www.youtube.com/watch?v=F2COZ97gCVo
    - Professor Dave Explains youtube site: https://www.youtube.com/@ProfessorDaveExplains