Medical Pharmacology: Immunopharmacology (Immunosuppressants/Immunomodulators) Practice Questions

Medical Pharmacology: Immunopharmacology (Immunosuppressants/Immunomodulators) Practice Questions

(Anti-IL-2 receptor antibodies (anti-CD25 a.k.a.IL-2Rα))

Click on the correct answer.

Interleukins:
1. Group of cytokines (secreted protein/signaling molecules)
2. Expressed and secreted by leukocytes (white blood cells)
3. Both
4. Neither
Immune system functionality mainly depends on interleukins.
1. True
2. False
Most interleukins are synthesized by CD4 helper T-lymphocytes.
1. True
2. False
The interleukin-2 receptor (IL-2R):
1. Present on some immune cells such as lymphocytes.
2. IL-2 cytokine binds and activates the interleukin-2 receptor.
3. Both
4. Neither
Immunomodulation may be effectuated by anti-IL-2 receptor antibodies (anti-CD25 a.k.a.IL-2Rα (Interleukin-2 receptor α chain) that bind to the α subunit of the IL-2 receptor.
1. True
2. False
Daclizumab (Zinbryta), an anti-CD25 antibody:
Note this agent is no longer available, discontinued by the manufacturer worldwide, due to safety concerns.
1. Described as a "humanized murine complementary-determining region/human IgG1 chimeric mAb (monoclonal antibody).
2. This anti-CD25 mAb exhibits high affinity binding to the IL-2 receptor α subunit.
3. Both
4. Neither
Daclizumab (Zinbryta):
1. IL-2 receptor antagonist (α chain)
2. Inhibits both T-cell activation and proliferation.
3. Both
4. Neither
Basiliximab (Simulect):
1. Chimeric mouse-human monoclonal antibody targeted at the α chain (CD25) of the T-cell IL-2 receptor.
2. Often used with other agents in the prevention of organ rejection.
3. Both
4. Neither
Basiliximab: Anti-CD25 antibody (CD25 is expressed only on activated T cells)
1. True
2. False
Daclizumab (Zinbryta): withdrawn from market due to safety concerns.
1. True
2. False

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Source Material:

Rothlin C Gutkind J Chapter 39 Immunosuppressants, Immunomodulation and Tolerance In Goodman & Gilman's The Pharmacological Basis of Therapeutics (Brunton LL Knollman BC eds) McGraw Hill LLC (2023).

Lake D & Briggs A Ch 55 Immunopharmacology in Katzung's Basic & Clinical Pharmacology (Vanderah TW, ed) 16e McGraw Hill 2023.

Chrouos G Ch 39 Adrenocorticosteroids & Adrenocortical Antagonists in Katzung's Basic & Clinical Pharmacology (Vanderah TW, ed) 16e McGraw Hill 2023

Brezinski E Klickstein L Armstrong A Ch 46 Pharmacology of Immunosuppression in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. (Golan DE Armstrong EJ Armstrong AW, eds) 4e 2017 ls) 4e 2017

Ritter JM Flower R Henderson G Loke YK MacEwan D Robinson E Fullerton J Ch 54 Anti-inflammatory and Immunosuppressant Drugs Rang & Dale's Pharmacology 10e Elsevier 2024.

Burchum J Rosenthal L Lehne's Pharmacology for Nursing Care Ch 72 Immunosuppressants Elsevier 2022.

Burchum J Rosenthal L Lehne's Pharmacology for Nursing Care Ch 75 Glucocorticoids in Nonendrocrine Disorders Elsevier 2022.

Bass A Rogatsky Ch 32 Immunomodulatory Drugs in Goldman-Cecil Medicine (Goldman L Schafer, eds) Elsevier 26e 2020

Leiva M Takemoto Ch 238 Immunosuppressants in Lippincott Illustrated Reviews: Pharmacology 8e ((Walen et al, eds) Wolters Kluwer 2023.

Hall J Hall M Ch 78 Adrenocortical Hormones Guyton and Hall Textbook of Medical Physiology 14e Elsevier 2021.

Waller DG Sampson A Hitchings Ch 38 A Medical Pharmacology & Therapeutics 6e Elsevier 2022