Interleukin-1 refers to it group of 11 cytokines constituting the IL-1 family.
IL-1 family: pro-inflammatory cytokines that by means of integrin expression on leukocyte and endothelial cells both initiate and regulate inflammatory responses.
Both
Neither
There is an naturally occurring IL-1 receptor blocker, IL-1 RA; furthermore, other synthetic IL-lRAs have been developed.
True
False
IL-1:
IL-1 levels in patients with active inflammation are elevated.
Anakinra (Kineret) is drug classified as an IL-1 receptor blocker.
Both
Neither
Anakinra: clinical use/uses
Second line therapy for management of rheumatoid arthritis if prior treatment with a DMARD (disease-modifying antirheumatic drug) has proven ineffective.
Effective in treating Schnitzler's syndrome.
Both
Neither
Anakinra:
Recombinant, nonglycosylated form of human IL-1 RA
In addition to rheumatoid arthritic joint disease, anakinra may also be used for
cryopyrin-associated periodic syndromes (CAPS).
Both
Neither
Anakinra may be administered for treating neonatal-onset multisystem inflammatory disorder.
True
False
Anakinra:
May be administered as monotherapy
May be administered in combination with anti-TNF drugs including adalimumab, infleximab, and etanercept
Both
Neither
Anakinra is an antagonist of IL-1α as well as IL-1β on IL-1 receptors.
True
False
Anakinra in clinical use:
This agent exhibits modest effects with respect to pain and swelling in rheumatoid arthritis.
Anakinra more significantly decreases bone erosion perhaps is the result of reduced osteoclast production and blockade of IL-1-elevated metalloproteinase release from synovial cells.
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