Brodalumab (Siliq): FDA approved for moderate to severe plaque psoriasis therapy.
True
False
Brodalumab (Siliq):
Binds to the IL-17 cytokine thus inhibiting receptor binding.
Binds to the IL-17 receptor, thus blocking brodalumab access.
Brodalumab (Siliq):
Treatment for moderate to severe plaque psoriasis in adults the of previously been treated unsuccessfully with topical or other systemic drugs.
Evaluated as potential treatment in psoriatic arthritis.
Both
Neither
Brodalumab (Siliq), as the result of IL-17 receptor blockade prevents:
Release of IL-7 mediated protein kinases that promote inflammation.
Chemokine release such as nuclear factor
κ light chain enhancer of activated B-cell (NF-κ-B)
Both
Neither
Inhibitor of the IL-17 pathway that not only may be used to treat plaque psoriasis but also exhibits the concerning side effect of suicidal ideation and behavior.
Secukinumab (Cosentyx)
Brodalumab (Siliq)
Ixekizumab (Taltz)
Fully human monoclonal antibodies directed against IL-17A
Brodalumab (Siliq)
Ixekizumab (Taltz)
Brodalumab (Siliq)
A & B
B & C
A & C
A, B & C
Cell types/types responding to IL-17-promoted proinflammatory cytokine production.
Kerotinocytes
Fibroblasts
Both
Either
Cell types/types responding to IL-17-promoted proinflammatory cytokine production.
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