Caplacizumab (Cablivi): Treatment
of Acquired Thrombotic Thrombocytopenic Purpura
Click on the correct answer.
Caplacizumab (Cablivi):
Von Willebrand factor-directed (vWF-directed) antibody fragment characterized by two humanized components linked by a 3-alanine
linker
Produced using recombinant DNA technology in an
E. coli system.
Both
Neither
Caplacizumab (Cablivi) clinical indication: for adult patients with acquired thrombotic thrombocytopenic purpura (aTTP).
True
False
Caplacizumab (Cablivi) is clinically used along with plasma exchange in immunosuppressive treatment for management of acquired thrombotic thrombocytopenic purpura.
True
False
Frequently noted adverse reaction (>15% of patients):
Epistaxis (Nosebleed)
Headache
Gingival bleeding
A & B
B & C
A & C
A, B & C
Notable drug interactions for Cablivi include concurrent use of anticoagulants or antiplatelet drugs.
True
False
Caplacizumab administration inhibits interaction between von Willebrand factor and platelets.
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