Humanized Monoclonal
Antibodies: Treatment of patients with Frequent Migraine Headaches
Click on the correct answer.
Eptinezumab ( Vyepti) acts by inhibiting calcitonin gene-related peptide binding to its receptor, thus helping to prevent migraines.
True
False
Eptinezumab is classified as CGRP (calcitonin gene-related peptide)
True
False
Erenumab (Aimovig), similar to eptinezumab binds to the CGRP receptor, preventing its activation and consequently is useful in preventing migraine.
True
False
Route of administration/administrations of erenumab (Aimovig):
Intravenous
Subcutaneous
Oral
Frequently observed side effect(s) associated with erenumab administration include/includes:
Constipation
Pruritus
Muscle spasms
A & B
A, B & C
None of the above
Erenumab (Aimovig):
Human monoclonal antibody
Bioavailability about 80% following subcutaneous administration
Both
Neither.
Fremanezumab (Ajovy):
Fully humanized monoclonal antibody
Targeting calcitonin gene-related peptides
α and β
Both
Neither
Fremanezumab interacts with some other anti-migraine drugs such as triptans, analgesics and ergot alkaloids
True
False
Galcanezumab (Emgality): humanized monoclonal antibody which may be used for:
Migraine prevention
Management of cluster headaches
Both
Either
Galcanezumab, by blocking calcitonin gene-related peptide, limits this peptide's ability to widen brain blood vessels. Expansion of blood vessels appears implicated in migraine development.
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