Medical Pharmacology: Immunopharmacology (Immunosuppressant/Immunomodulators) Practice Questions
Abciximab (Reopro)
Click on the correct answer.
Abciximab (Reopro):
Platelet aggregation inhibitor
Glycoprotein receptor antagonist
Both
Neither
Antiplatelet classifications. Which one/ones of the following is/are correct?
Platelet aggregation inhibitors: e.g. cyclooxygenase inhibitors
Protease-activated receptor-1 antagonist e.g.
vorapaxar (Zontivity)
Glycoprotein platelet inhibitors: abciximab, eptifibitide, tirofiban (Aggrastat and others)
A & B
B & C
A, B & C
Abciximab (Reopro) pharmacokinetics:
Short plasma half-life
Extended pharmacological activity due to strong
platelet receptor affinity
Both
Neither
Abciximab (Reopro) dose must be adjusted in patients with renal failure.
True
False
Abciximab (Reopro):
Fab fragment of a mouse-human monoclonal antibody.
Abciximab binds to the integrin (GPIIb/IIIa) receptor localized on activated platelets.
Both
Neither
Abciximab (Reopro):
Inhibits fibrinogen binding to activated platelets
Inhibits von Willebrand factor binding to activated platelets
Both
Neither
Abciximab (Reopro) inhibits fibrinogen, von Willebrand factor and another adhesion molecules from binding to activated platelets which prevents aggregation of these components.
True
False
Abciximab (Reopro) may be used along with aspirin and heparin in percutaneous coronary procedures, thus reducing the likelihood of cardiac ischemic-related adverse effects.
True
False
Abciximab (Reopro), as well as other members of the glycoprotein platelet inhibitor group, may be administered either orally or by IV.
True
False
Abciximab (Reopro) is typically used in short-term therapy.
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