LDL lipoprotein particles transport fat molecules including cholesterol.
Both
Neither
Alirocumab (Praluent) and PCSK9: LDL liver receptors promote ingestion of LDL-particles into cells ultimately leading to lysosomal-mediated destruction.
True
False
Alirocumab (Praluent) and PCSK9:
Blockade of PCSK9 results in LDL digestion in the lysosome while the LDL receptor translocates to the cell membrane enabling removal of additional LDL particles from blood.
Drug/drugs that reduce LDL particle levels in blood via the PCSK9 inhibition mechanism.
Alirocumab (Praluent)
Evolocumab (Repatha)
Both
Neither
Mechanism of action relating to reducing LDL levels involves increasing LDL processing and clearance prior to LDL formation is associated with evinacumab (Evkeeza)
True
False
Evinacumab: FDA approved for reducing cholesterol in patients (>5 years of age) diagnosed with homozygous familial hypercholesterolemia.
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