Medical Pharmacology: Immunopharmacology (Immunosuppressants/immunomodulators) Practice Questions
Denosumab (Prolia): Bone
Anti-Resporptive Agent
Click on the correct answer.
Denosumab (Prolia):
Competitive inhibitor of NF kappa B ligand (RANKL) at the receptor.
Murine IgG1 monoclonal antibody
Both
Neither
Denosumab (Prolia) Use/uses:
Osteoporosis
Bone metastases
Both
Neither
Denosumab (Prolia):
Inhibits osteoclast maturation
Appropriate for use in patients (men and women) with elevated risk for bone fracture due to glucocorticoid -induced osteoporosis, androgen deprivation (men),
and aromatase inhibitor treatment for breast cancer.
Both
Neither
Denosumab (Prolia): Before initiating therapy with this agent, patients must be checked to be certain they are not hypocalcemic.
True
False
During treatment with denosumab calcium and vitamin D supplementation is appropriate.
True
False
In the context of hypocalcemia associated with malignancy, denosumab administration may be appropriate if hypercalcemia is not responsive to bisphosphonate therapy.
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Chrouos G Ch 39 Adrenocorticosteroids &
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Pharmacology of Immunosuppression in Principles of
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for Nursing Care Ch 72 Immunosuppressants Elsevier 2022.
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Immune Response and Immunosuppressant Drugs
Medical Pharmacology & Therapeutics 6e Elsevier 2022
Waller DG Sampson A Hitchings Ch 30
Rheumotoid Arthritis, Other Inflammatory Arthrides and
Osteoarthritis Medical Pharmacology & Therapeutics 6e
Elsevier 2022