Medical Pharmacology: Immunopharmacology (Immunosuppressants/Immunomodulators) Practice Questions

"Complement-directed therapy for cold agglutinin disease: sutimlimab"

  • Attribution:

    • Figure 1. "The role of the complement pathway in CAD and mechanism of action of sutimlimab. C, complement protein; IG, immunoglobulin; MAC, membrane attack complex; MBL, mannose-binding lectin; RBC, red blood cell.

    • Attribution: Broome C Complement-directed therapy for cold agglutinin disease: sutimlimab Expert Review of Hematology 16 (7) 479-494 (2023). https://www.tandfonline.com/doi/full/10.1080/17474086.2023.2218611#d1e132

 

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  • Source Material:

    • Rothlin C Gutkind J Chapter 39 Immunosuppressants, Immunomodulation and Tolerance In Goodman & Gilman's The Pharmacological Basis of Therapeutics (Brunton LL Knollman BC eds) McGraw Hill LLC (2023). 

    • Lake D & Briggs A Ch 55 Immunopharmacology in Katzung's Basic & Clinical Pharmacology (Vanderah TW, ed) 16e McGraw Hill 2023.

    • Sutimlimab https://en.wikipedia.org/wiki/Sutimlimab

    • Broome C Complement-directed therapy for cold agglutinin disease: sutimlimab Expert Review of Hematology 16 (7) 479-494 (2023). Attribution: Broome C Complement-directed therapy for cold agglutinin disease: sutimlimab Expert Review of Hematology 16 (7) 479-494 (2023). https://www.tandfonline.com/doi/full/10.1080/17474086.2023.2218611#d1e132

    • Roth A Barcellini W Shirley D'Sa Miyakawa Y Boome C Michel M Kuter D Berentsen S Sutimlimab in Cold Agglutinin Disease N Engl J Med 2021; 384: 1323-1334 https://www.nejm.org/doi/full/10.1056/NEJMoa2027760.

    • Cold Agglutinin Disease https://en.wikipedia.org/wiki/Cold_agglutinin_disease

    • Chrouos G Ch 39 Adrenocorticosteroids & Adrenocortical Antagonists in Katzung's Basic & Clinical Pharmacology (Vanderah TW, ed) 16e McGraw Hill 2023

    • Brezinski E Klickstein L Armstrong A Ch 46 Pharmacology of Immunosuppression in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. (Golan DE Armstrong EJ Armstrong AW, eds) 4e 2017

    • Ritter JM Flower R Henderson G Loke YK MacEwan D Robinson E Fullerton J Ch 25 Anti-inflammatory and Immunosuppressant Drugs Rang & Dale's Pharmacology 10e Elsevier 2024.

    • Burchum J Rosenthal L Lehne's Pharmacology for Nursing Care Ch 72 Immunosuppressants Elsevier 2022.

    • Burchum J Rosenthal L Lehne's Pharmacology for Nursing Care Ch 75 Glucocorticoids in Nonendrocrine Disorders Elsevier 2022.

    • Burchum J Rosenthal L Lehne's Pharmacology for Nursing Care Ch 76 Drug Therapy for Rheumatoid Arthritis Elsevier 2022.

    • Bass A Rogatsky Ch 32 Immunomodulatory Drugs in Goldman-Cecil Medicine (Goldman L Schafer, eds) Elsevier 26e 2020

    • Leiva M Takemoto Ch 238 Immunosuppressants in Lippincott Illustrated Reviews: Pharmacology 8e ((Walen et al, eds) Wolters Kluwer 2023.

    • Hall J Hall M Ch 78 Adrenocortical Hormones Guyton and Hall Textbook of Medical Physiology 14e Elsevier 2021.

    • Waller DG Sampson A Hitchings Ch 38 The Immune Response and Immunosuppressant Drugs  Medical Pharmacology & Therapeutics 6e Elsevier 2022

    • Waller DG Sampson A Hitchings Ch 30 Rheumotoid Arthritis, Other Inflammatory Arthrides and Osteoarthritis Medical Pharmacology & Therapeutics 6e Elsevier 2022