Atoltivimab, Maftivimab, and
Odesivimab (Inmazeb) and Ansuvimab (Ebanga): Zaire Ebolavirus Antivirals
Click on the correct answer.
Useful in treating
Zaire ebolavirus:
Ansuvimab (Ebanga)
Atoltivimab
Maftivimab
Odesivimab
A
B, C, D
A, B, C, D
Ebola virus disease (EVD) previously called Ebola hemorrhagic fever is associated with severe, frequently fatal illness.
True
False
Ebola virus:
Single-stranded negative-sense RNA surrounded by lipid membrane envelope
This virus is spread by direct contact with blood or other bodily fluids from infected individuals (or animals).
Both
Neither
Monoclonal antibody treatment (FDA-approved) confer increased overall and has been evaluated for effectiveness against Zaire ebolavirus.
True
False
The combination of three recombinant human IgG1 monoclonal antibodies: atoltivimab, maftivimab and odesivimab is provided as Inmazeb.
True
False
Inmazeb as well as Ebanga (ansuvimab) target the cell surface Zaire ebolaviral glycoprotein.
True
False
The mAb (monoclonal antibody) "cocktail" consisting of atoltivimab, maftivimab, and odesivimab (Inmazeb):
Neutralizes Zaire Ebola infection
This combination has been approved for both adult and pediatric infected patients.
Both
Neither
Patients receiving either the Mab cocktail, Inmazeb, or ansuvimab should not receive the Ebola vaccine fully several months. Otherwise, vaccine efficacy could be compromised.
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