Janus kinase/signal transducer which activates JAK-STAT signaling pathway:
Fast membrane-to-nucleus signaling system
Activation influences expression of cancer
and inflammation mediators
Both
Neither
JAK-STAT signaling pathway appears to influence:
Hematopoiesis
Immune fitness
Both
Neither
The JAK family involves non-receptor tyrosine protein kinases
True
False
The JAK family:
JAK tyrosine kinase activation
JAK tyrosine kinase activation is associated with transmission of regulatory signals.
Both
Neither
In treating many autoimmune diseases, inhibition of immune modulating cytokines by means of JAK inhibitors, has proven clinically beneficial.
True
False
The number of JAK inhibitors are available for use in humans including two combined JAK1 and JAK2 inhibitors, three JAK1 inhibitors, two JAK2 inhibitors, a JAK1, JAK2 and JAK3 inhibitor
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