Ruxolitinib (Jakafi): Approved in 2019 for managing steroid-refractory acute graft-versus-host disease in both children and adults.
True
False
Ruxolitinib (Jakafi):
Useful in treating polycythemia vera subsequent to inadequate response
to or intolerance of hydroxyurea.
FDA-approved drug for treating non-segmental vitiligo in both pediatric and adult patients >12 years of age. Ruxolitinib (Opzelura (cream)) FDA-approved drug treatment addressing repigmentation in vitiligo patients.
Both
Neither
Ruxolitinib (Jakafi): Side effects
Most common side effect in myelofibrosis treatment : thrombocytopenia, neutropenia, anemia and others
Most common side effect in polycythemia vera: anemia and thrombocytopenia as well as hypertriglyceridemia.
Both
Neither
Ruxolitinib (Jakafi) Pharmacokinetics
Half-life: three hours (parent drug); six hours (active metabolites)
Hepatic metabolism utilizing the cytochrome P450 drug metabolizing system particularly isoform CYP2C9 and CYP3A4.
Rothlin C Gutkind J
Chapter 39 Immunosuppressants, Immunomodulation and
Tolerance In Goodman & Gilman's The Pharmacological Basis of
Therapeutics (Brunton LL Knollman BC eds) McGraw Hill LLC
(2023).
Brezinski E Klickstein L Armstrong A Ch 46 Pharmacology of Immunosuppression in Principles of Pharmacology: The
Pathophysiologic Basis of Drug Therapy. (Golan DE Armstrong
EJ Armstrong AW, eds) 4e 2017
Ritter JM Flower R
Henderson G Loke YK MacEwan D Robinson E Fullerton J Ch 25
Anti-inflammatory and Immunosuppressant Drugs Rang & Dale's
Pharmacology 10e Elsevier 2024.
Burchum J Rosenthal L
Lehne's Pharmacology for Nursing Care Ch 72
Immunosuppressants Elsevier 2022.
Burchum J Rosenthal L
Lehne's Pharmacology for Nursing Care Ch 75 Glucocorticoids
in Nonendrocrine Disorders Elsevier 2022.
Burchum J Rosenthal L
Lehne's Pharmacology for Nursing Care Ch 76 Drug Therapy for
Rheumatoid Arthritis Elsevier 2022.
Bass A Rogatsky Ch 32
Immunomodulatory Drugs in Goldman-Cecil Medicine (Goldman L
Schafer, eds) Elsevier 26e 2020
Leiva M Takemoto Ch
238 Immunosuppressants in Lippincott Illustrated Reviews:
Pharmacology 8e ((Walen et al, eds) Wolters Kluwer 2023.
Hall J Hall M Ch 78
Adrenocortical Hormones Guyton and Hall Textbook of Medical
Physiology 14e Elsevier 2021.
Waller DG Sampson A
Hitchings Ch 38 The Immune Response and Immunosuppressant
Drugs Medical Pharmacology & Therapeutics 6e Elsevier
2022
Waller DG Sampson A
Hitchings Ch 30 Rheumotoid Arthritis, Other Inflammatory
Arthrides and Osteoarthritis Medical Pharmacology &
Therapeutics 6e Elsevier 2022
