Medical Pharmacology: Immunopharmacology and Janus Kinase Inhibitors (JAK Inhibitors)

 

"Signaling pathways in the pathogenesis of RA" (Rheumatoid Arthritis)
  • "Main signaling pathways in their inhibitors related to RA. The JAK signaling pathway,

    • Notch signaling pathway, MAPK signaling pathway, Wnt signaling pathway,PI3K signaling pathway, and SYK signaling pathway are the main signaling pathways involved in the process of RA, related signalings are often the potential targets for drug discovery"

  • Attribution:

 

Filgotinib (Jyseleca):  Janus Kinase Inhibitior

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  • Source Material:

    • Rothlin C Gutkind J Chapter 39 Immunosuppressants, Immunomodulation and Tolerance In Goodman & Gilman's The Pharmacological Basis of Therapeutics (Brunton LL Knollman BC eds) McGraw Hill LLC (2023).

    • Filgotinib https://en.wikipedia.org/wiki/Filgotinib

    • Lake D & Briggs A Ch 55 Immunopharmacology in Katzung's Basic & Clinical Pharmacology (Vanderah TW, ed) 16e McGraw Hill 2023.

    • Kafaja T Anwar S Furst D Ch 36 Non Steroidal Anti-Inflammatory Drugs, Disease-Modifiying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout Katzung's Basic & Clinical Pharmacology (Vanderah TW, ed) 16e McGraw Hill 2023.

    • Dhillon S Kearn S Filgotinib: First Approval Drugs 80, 1987-1997 (2020); https://link.springer.com/article/10.1007/s40265-020-01439-0

    • Namour F Anderson K Nelson C Tasset C Filgotinib: A Clinical Pharmacology Review Clin Pharmacokinet. 22 Jun; 61(6): 819-832. https://pubmed.ncbi.nlm.nih.gov/35637376

    • Ding Q Hu W Wang R et al. Signaling pathways in rheumatoid arthritis: implications for targeted therapy. Sig Transduct Target Ther  8, 68 (2023) https://www.nature.com/articles/s41392-023-01331-9

    • Brezinski E Klickstein L Armstrong A Ch 46 Pharmacology of Immunosuppression in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. (Golan DE Armstrong EJ Armstrong AW, eds) 4e 2017

    • Ritter JM Flower R Henderson G Loke YK MacEwan D Robinson E Fullerton J Ch 25 Anti-inflammatory and Immunosuppressant Drugs Rang & Dale's Pharmacology 10e Elsevier 2024.

    • Burchum J Rosenthal L Lehne's Pharmacology for Nursing Care Ch 72 Immunosuppressants Elsevier 2022.

    • Burchum J Rosenthal L Lehne's Pharmacology for Nursing Care Ch 75 Glucocorticoids in Nonendrocrine Disorders Elsevier 2022.

    • Burchum J Rosenthal L Lehne's Pharmacology for Nursing Care Ch 76 Drug Therapy for Rheumatoid Arthritis Elsevier 2022.

    • Bass A Rogatsky Ch 32 Immunomodulatory Drugs in Goldman-Cecil Medicine (Goldman L Schafer, eds) Elsevier 26e 2020

    • Leiva M Takemoto Ch 238 Immunosuppressants in Lippincott Illustrated Reviews: Pharmacology 8e ((Walen et al, eds) Wolters Kluwer 2023.

    • Hall J Hall M Ch 78 Adrenocortical Hormones Guyton and Hall Textbook of Medical Physiology 14e Elsevier 2021.

    • Waller DG Sampson A Hitchings Ch 38 The Immune Response and Immunosuppressant Drugs  Medical Pharmacology & Therapeutics 6e Elsevier 2022

    • Waller DG Sampson A Hitchings Ch 30 Rheumotoid Arthritis, Other Inflammatory Arthrides and Osteoarthritis Medical Pharmacology & Therapeutics 6e Elsevier 2022