May be used in treating systemic lupus erythematosus
Both
Neither
Tofacitinib (Xeljanz):Clinical use/uses:
Rheumatoid arthritis,
Ankylosing spondylitis
Ulcerative colitis
A & B
B & C
A & C
A, B & C
Tofacitinib (Xeljanz) Clinical use/uses:
Juvenile idiopathic arthritis
Psoriatic arthritis
Both
Neither
Tofacitinib (Xeljanz)
Synthetic small-molecule
Orally active inhibitor of Janus kinases
Both
Neither
Tofacitinib (Xeljanz): Concerning the use of tofacitinib in rheumatoid arthritis, the drug is typically used for those adult patients either unresponsive or having developed intolerance to disease-modifying rheumatoid drugs (DMARDS).
True
False
Tofacitinib (Xeljanz): Concerning tofacitinib clinical use in treating poly articular course juvenile idiopathic arthritis, this drug may be administered orally to patients two years and older.
True
False
Tofacitinib mechanism of action: inhibiting cytoplasmic nonreceptor tyrosine kinase JAK enzymes that are involved in immune-mediated inflammatory disorders.
True
False
Tofacitinib pharmacokinetics:
Metabolism: hepatic, CYP3A4
Terminal half-life is about
3 hours
Both
Neither
Tofacitinib pharmacokinetics: Mainly, tofacitinib is excreted in the urine (80%); the remainder in the feces (14%)
True
False
Given the importance of hepatic metabolism for tofacitinib, this drug should not be given to individuals exhibiting severe liver disease.
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