Medical Pharmacology Chapter 41:  Anti-inflammatory Agent Practice Questions

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Mediator of acute inflammation
Mediator of chronic inflammation
Cell type: source for the chronic inflammation mediator TNF alpha
Primary Effect of TNF alpha in chronic inflammation:
May slow bone damage associated with rheumatoid arthritis
Reduces pharmacological activity of spironolactone, competes with penicillin G. for renal tubular secretion;inhibits probenecid uricosuric effect
Salicylate, but less effective than aspirin as cyclooxygenase inhibitors
Transaminitis (increase serum aminotransferase)
Infusion of this drug: accelerates closure of patent ductus arteriosus in premature newborns

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