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Targeted Cancer Therapy

Imatinib (Gleevac) as a Paradigm of Targeted Cancer Therapies (Click to go to Content)

  • Attribution:

    • Druker BJ Imatinib (Gleevec) as a Paradigm of Targeted Cancer Therapeies (Part I:  Imatinib (Gleevec:  A Targeted Cancer Therapy)  March 29, 2010

    • "Imatinib (Gleevec) has become a paradigm for targeted cancer therapies.

      • "The first part of this lecture will describe the clinical features and the molecular pathogenesis of the disease for which imatinib was developed, chronic myeloid leukemia (CML).

      • "This overview will trace the history of the identification of the target of imatinib, BCR-ABL.

      • "The preclinical development of the BCR-ABL kinase inhibitor, imatinib and highly successful clinical trials of this agent for patients with CML will be reviewed along with the most up-to-date follow-up on these studies."17

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