Medical Pharmacology Chapter 25: Pulmonary Pharmacology Practice Questions

Which one(s) of the following is/are associated with asthma, chronic airway inflammatory disease?
1. Activation of mast cells
2. Infiltration of innate type 2 lymphocytes (ILC 2)
3. Both
4. Neither
Which one(s) of the following is/are associated with asthma, chronic airway inflammatory disease?
1. Eosinophil infiltration
2. Infiltration of T helper 2 (TH2) lymphocytes.
3. Both
4. Neither
Consequence(s) of allergen-induced mast cell activation and bronchoconstrictor mediator release?
1. Microvascular leakage
2. Plasma exudation
3. Bronchodilation
4. A & B
5. B & C
6. A & C
7. A, B & C
Example(s) of bronchoconstrictor mediators which may be released by physical stimuli
1. Prostaglandin D2
2. Leukotriene D4 (LTD4)
3. Histamine
4. A & B
5. B & C
6. A & C
7. A, B & C
Airway smooth muscle contraction appears responsible for the majority of asthma symptoms.
1. True
2. False
Which one(s) of the following statements is/are correct?
1. Multiple inflammatory mediators are released by the airway epithelium.
2. Airway epithelium is involved in growth factor release as part of damage repair; damageas a result of inflammation.
3. Both
4. Neither
Airway consequences due to chronic inflammation:
1. More airway smooth muscle cells
2. Larger airway smooth muscle cells
3. Fewer mucus-secreting cells
4. Reduced number of blood vessels
5. A & B
6. B & C
7. A & C
8. A, B & C
9. A, B, C & D (all responses are correct)
Typical timeframe for asthma onset:
1. Early childhood
2. Adolescence
3. Adulthood
Characteristic(s) of asthma:
1. Responsive to corticosteroids and bronchodilators for therapeutic management.
2. Associated with variable airflow obstruction
3. Characterized by consistent and persistent reduced airflow
4. A & B
5. B & C
6. A & C
7. A, B & C
An insidious characteristic of asthma involves progression from mild asthma to severe asthma
1. True
2. False