Medical Pharmacolgy Chapter 22: Serotonin Pharmacology

The brainstem vomiting center receives input from various sources. Which one of the following sources are rich in serotonin (5-HT3) receptors?
1. Vestibular system
2. Gastrointestinal viscera
3. Both
4. Neither
The chemoreceptor trigger zone localized in the medullary area postrema (outside the blood brain barrier) is associated with which one(s) of the following receptor system(s)?
1. Dopamine (D2)
2. Serotonin (5-HT3)
3. Neurokinin 1 (NK1)
4. Opioid receptors
5. A & B
6. B & C
7. A & C
8. A, B & C
9. All the receptor systems (A, B, C & D)
Activation of the amygdala by smells, emotional experiences etc. may cause vomiting.
1. True
2. False
Which one(s) of the following drugs are classified as serotonin (HT-3) receptor blockers?
1. Palonosetron (Aloxi)
2. Dolasetron (Anzemet)
3. Granisetron (Kytril)
4. Ondansetron (Zofran)
5. All of the above
More likely to be used in reducing the incidence or preventing nausea and vomiting postoperatively.
1. Droperidol
2. Ondansetron
3. Both
4. Neither
Dexamethasone and other corticosteroids exhibit antiemetics characteristics.
1. True
2. False
Corticosteroids increase serotonin receptor blocker efficacy with respect to limiting acute and delayed nausea and vomiting in individuals receiving emetogenic chemotherapy drugs.
1. True
2. False
Corticosteroids and serotonin blockers may be used in combination with this agent in limiting nausea and vomiting associated with administration of highly emetogenic chemotherapy drugs.
1. Fosaprepitant (Emend)
2. Rolapitant (Varubi)
3. Aprepitant (Emend)
4. A & B
5. All of the above (A, B & C)
Considering the atypical antipsychotic drug olanzapine (Zyprexa), choose the correct statements/statements?
1. Olanzapine (Zyprexa) exhibits enzymatic properties.
2. Antiemetic properties associated with olanzapine is likely mediated via muscarinic, cholinergic receptors.
3. Both
4. Neither
Serotonin is found in highest concentration in the G.I. tract and in blood platelets.
1. True
2. False