Medical Pharmacology: Vasoactive Peptide Practice Questions
Choose the correct answer for each question.
Which one(s) of the following statements is/are correct concerning kinins?
- Kinins are effective vasoconstrictor peptides
- The synthesis of kinins is catalyzed by kallikreins.
- Kallikreins act on substrates called kininogens.
- A & B
- B & C
- A & C
- A, B & C
Kallikreins are categorized as this type of enzyme
- Carboxypeptidase
- Transaminase
- Serine protease
Kallikreins are located in plasma and in some organs.
- True
- False
Kallikreins are secreted as zymogens and subsequently activated (proteolytic cleavage).
- True
- False
Plasma prekallikrein requires activated blood coagulation factor XII (FXIIa).
- True
- False
Kinin(s) considered major prominent in humans.
- Bradykinin
- Lys-bradykinin
- Both
- Neither
Released from high molecular weight kininogen through the action of plasma kallikrein:
- Kallidin (Lys-bradykinin)
- Bradykinin
Low-molecular-weight kininogen acted on by tissue kallikrein is the kallidin precursor.
- True
- False
Prominent kinin in plasma:
- Lys-bradykinin
- Bradykinin
- Both
- Neither
Kinins are characterized by relatively slow metabolism.
- True
- False
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