Many enzymes exhibit stereoselectivity,
a preference for one or the other
enantiomeric form:
In the case of
drug-metabolizing enzymes, stereoselectivity
may result in a difference in the duration
of action of one enantiomer compared
to the other.
Structure Activity
Relationships:
Understanding the
relationship between drug structures and
biological activities forms the basis of
rational drug design.
Computer-enhanced molecular
modeling and information concerning
three-dimensional receptor structure may
combine to improve the effectiveness of
rational drug design approaches.
above to
begin
