Nursing Pharmacology: Antibacterial Drug Practice Questions

Sulfonamide drugs represent the first chemotherapeutic agent which was used generally for both prevention and cure of human bacterial infections.
1. True
2. False
Sulfanilamides:
1. Derivatives of para- aminobenzenesulfonamide
2. Congeners of PABA
3. Both
4. Neither
Organisms that are susceptible to sulfonamide antibacterial drugs:
1. Are unable to use exogenous folate
2. Folate synthesis depends on para-aminobenzoic acid
3. Both
4. Neither
Trimethoprim inhibits this enzyme in the purine/nucleic acid synthesis pathway:
1. Dihydropteroate synthase
2. Dihydrofolate reductase
3. Both
4. Neither
Sulfonamides are a competitive inhibitor of this enzyme (competing with para-aminobenzoic acid (PABA))
1. Dihydrofolate reductase
2. Dihydropteroate synthase
3. Both
4. Neither
This organism is not inhibited but rather stimulated by sulfonamide antibacterial agents.
1. Staphylococcus
2. Rickettsiae
3. Shigella
4. Salmonella
Pseudomonas aeruginosa is inherently resistant to sulfonamide antibacterials:
1. True
2. False
Synergistic activity: combination of trimethoprim + sulfonamide:
1. True
2. False
Concerning use of sulfonamides in treating urinary tract infections:
1. Coliform bacteria represent the most likely cause of UTI and are moderately inhibited by sulfonamide antibacterials:
2. Resistance by E. coli to sulfonamides is common.
3. Both
4. Neither
Sulfonamide pharmacology:
1. Sulfonamides are classified as bacteriocidal.
2. Host cellular and hormonal immunological mechanisms are needed for infection eradication.
3. Both
4. Neither
Generally, sulfonamides are well absorbed from the G.I. tract (70%-100% of an oral dose).
1. True
2. False
Sulfonamide pharmacokinetics:
1. Peak plasma levels: noted in 2-6 hours
2. The major site of absorption = stomach
3. Both
4. Neither
Sulfonamide pharmacology:
1. Sulfadiazine and sulfisoxazole may be effective in meningitis but due to sulfonamide-resistant organisms, these agents are seldom used for this purpose.
2. Sulfonamides, passing through the placenta, will reach fetal circulation.
3. Both
4. Neither
Sulfonamide metabolism:
1. Principally hepatic with the drug eliminated both in the unchanged form and as Metabolites.
2. Most of the drug will be excreted in the urine
3. Both
4. Neither
Relatively small amounts of sulfonamides may be found eliminated in the feces, bile and other secretions.
1. True
2. False