Nursing Pharmacology: Antibacterial Drug Practice Questions
Click on the correct answer.
Trimethoprim (Primsol, Trimpex):
Protein binding: about 45%
Metabolism: partially by the liver (10%-20%)
Both
Neither
Trimethoprim (Primsol) excretion: mainly in the urine, about 55% with about 80% present as the unchanged, parent drug.
True
False
Therapeutic clinical applications of trimethoprim-sulfamethoxazole:
Bacterial respiratory tract infections: appropriate for mild but acute worsening of chronic bronchitis.
Effective in treating pediatric acute otitis media in children as well as acute maxillary sinusitis in adults when the causative susceptible strains are H. influenzae and
S. pneumoniae.
Both
Neither
Trimethoprim and trimethoprim sulfamethoxazole are appropriate for preventing or treating traveler's diarrhea.
True
False
Trimethoprim sulfamethoxazole is considered alternative medication to a fluroquinolone for treatment of shigellosis.
True
False
High-dose timethoprim-sulfamethoxazole:
Effective for treating
Pneumocystis jiroveci pneumonia.
Trimethoprim-sulfamethoxazole is effective in preventing
Pneumocystis jiroveci
Both
Neither
Trimethoprim-sulfamethoxazole:
Trimethoprim-sulfamethoxazole: may be useful in treating methicillin-resistant Staphylococcus aureus (MRSA) as adjunctive treatment to incision/drainage of complicated abscesses.
Trimethoprim-sulfamethoxazole is also standard therapy for treating invasive MRSA infections, including bacteremia
In folate-deficient patients, trimethoprim-sulfamethoxazole may induce: megaloblastosis, leukopenia or thrombocytopenia.
In patients with renal dysfunction secondary to sulfamethoxazole crystalluria, administration of trimethoprim-sulfamethoxazole may result in permanent renal function impairment.
Both
Neither
Trimethoprim: clinical use/uses:
Acute, uncomplicated cystitis
Otitis media:
Both
Neither
Trimethoprim in the setting of pregnancy:
Crosses the placenta
Adverse fetal occurrences may follow from maternal trimethoprim use immediately before during pregnancy.
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Source Material:
MacDougall C Chapter
56: Sulfonamides, Trimethoprim-Sulfamethoxazole,
Quinolones and Agents for Urinary Tract Infections in Goodman & Gilman's: The Pharmcological
Basis of Therapeutics, 13e, (Brunto LL Hilal-Dandan R Knollmann
BC, eds) McGraw-Hill Education, 2018.
Gruenberg K
Guglielmo BJ e1-13: Sulfonamides & Antifolate Medications in Current Medical Diagnosis & Treatment (Papadakis
MA McPhee SJ Rabow MW McQuaid KR, eds) 61e McGraw Hill 2022.
Beauduy; CE Winston
LG Chapter 46: Sulfonamides, Trimethoprim, & Quinolones
in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah
TW, Associate editor) 15e McGraw Hill 2021.
Drugs (Access
Medicine)
Gupta K Trautner BW
Chapter 135: Urinary Tract Infections, Pyelonephritis and
Prostatitis in Harrison's Principles of Internal Medicine 21st
Editions, Loscalzo J Fauci A Kasper D Hauser S Longo D Jameson
JL,eds) McGraw Hill LLC, 2022.
