Nursing Pharmacology: Antibacterial Drug Practice Questions

Nursing Pharmacology: Antibacterial Drug Practice Questions

Click on the correct answer.

The mechanism of action of ß-lactam antibacterial drugs is the inhibition of the final step in peptidoglycan synthesis.
1. True
2. False
ß-lactam antibiotics:
1. Inhibit cross-linking of glycan chains
2. Cross-linking of glycan chains is catalyzed by the enzyme transpeptidase
3. Both
4. Neither
ß-lactam antibiotics:
1. Act by acylating the transpeptidases enzyme by cleaving the -CO-N- bond of the ß-lactam ring.
2. Targets of anti-bacterial ß-lactam agents: collectively termed PBPs with the transpeptidases important for peptidoglycan synthesis being one of these PBPs.
3. Both
4. Neither
Bacterial lethality of penicillins involve/involves:
1. Nonlytic mechanisms
2. Lytic mechanisms
3. Both
4. Neither
Which one(s) of the following represent penicillin classes?
1. Anti-Staphlococcal penicillins, for example, nafcillin, which are resistant to Staphlococcal ß-lactamases.
2. Extended spectrum agents (e.g. aminopenicillins) exhibit reduced activity against gram-negative rods.
3. Penicillins such as penicillin G exhibit highest activity against gram-positive bacteria.
4. A & B
5. B & C
6. A & C
7. A, B & C
ß-lactam antibiotics:
1. Selective inhibitors of bacterial cell wall synthesis.
2. Active against growing bacteria.
3. Both
4. Neither
The first step of ß-lactam drug action is binding to penicillin-binding proteins (PBPs) cell receptors
1. True
2. False
ß-lactam antibiotics:
1. There are at least 6 different PBPs. Some of them are transpeptidases.
2. Binding to different PBP's may result in a different effect (e.g., penicillin binding to one PBP may result in abnormal cellular elongation; binding to another may induce cell lysis following a defect in cell wall structure.
3. Both
4. Neither
Inhibition of bacterial transpeptidase by cephalosporins and penicillins result from similarities of drug structures to acyl-D-alanyl-D-alanine.
1. True
2. False
Animal cells do not exhibit a cell wall similar to bacteria with this peptidoglycan structure. This difference accounts for the absence of toxicity of ß-lactam antibiotics to mammalian cells.
1. True
2. False

Previous Antibacterial Pharmacology Practice Question Set
Next Antibacterial Pharmacology Practice Question Set

If you wish to return to the Table of Contents in ENGLISH, press the RETURN button above.

Otherwise, if the text is NOT displayed in English and you are ready to leave this page, Press here to return to the Table of Contents

Source Material:
- MacDougall C Chapter 56: Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones and Agents for Urinary Tract Infections in Goodman & Gilman's: The Pharmcological Basis of Therapeutics, 13e, (Brunto LL Hilal-Dandan R Knollmann BC, eds) McGraw-Hill Education, 2018.
- MacDougall C Chapter 57 Penicillins, Cephalosporins, and Other ß-Lactam Antibiotics in Goodman & Gilman's: The Pharmcological Basis of Therapeutics, 13e, (Brunto LL Hilal-Dandan R Knollmann BC, eds) McGraw-Hill Education, 2018.
- Gruenberg K Guglielmo BJ e1-13: Sulfonamides & Antifolate Medications in Current Medical Diagnosis & Treatment (Papadakis MA McPhee SJ Rabow MW McQuaid KR, eds) 61e McGraw Hill 2022.
- Beauduy; CE Winston LG Chapter 43: Beta-Lactam & Other Cell Wall- & Membrane- Active Antibiotics in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah TW, Associate editor) 15e McGraw Hill 2021.
- Beauduy; CE Winston LG Chapter 46: Sulfonamides, Trimethoprim, & Quinolones in Basic & Clinical Pharmacology (Katzung BG, Editor; Vanderah TW, Associate editor) 15e McGraw Hill 2021.
- Gupta K Trautner BW Chapter 135: Urinary Tract Infections, Pyelonephritis and Prostatitis in Harrison's Principles of Internal Medicine 21st Editions, Loscalzo J Fauci A Kasper D Hauser S Longo D Jameson JL,eds) McGraw Hill LLC, 2022.
- Jawetz, Melnick, & Adelberg's Medical Microbiology (Riedel A Hobdfen JA Miller S Morse SA Mietzner TA Detrick B Mitchell TG Sakanari JA Hotez D Mejia R) 28e, 2019.
- Kubiak DW Arnaout RA Hammond SP Pharmacology of Bacterial and Mycobacterial Infections: Cell Wall Synthesis in Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. (Golan DE, editor-in chief, Armstrong EJ Armstrong AW, associate editors) 4e Wolters Kluwer 2017