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Overview
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Quinuprisin/dalfopristin (Synercid): properties
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two streptogramin
antibacterials (30:70 combination)
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Target: bacterial
ribosomes
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Effect: disruption of
protein synthesis
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Antibacterial
Characteristics:
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Active: against E. faecium
(not against Enterococcus
faecalis)
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Active (in vitro): against
methicillin (Staphcillin)-susceptible
and-resistant S. aureus and S.
epidermidis
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Active (in vitro): against
penicillin-susceptible &-resistant Streptococcus
pneumoniae
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Active (in vitro): against
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Neisseria
meningitidis, Moraxella
cattarrhalis, Legionella
pneumophila, Mycoplasma
pneumoniae, Clostridium
perfringens
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Pharmacokinetics
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IV administration
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hepatic metabolism
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biliary excretion
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Some clinical trial results:
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Adverse
Effects:
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Infusion site pain,
inflammation, edema, thrombophlebitis --
frequency: 75%
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Arthralgias & myalgias:
common, may be severe
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Drug-drug interactions
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Clinical Use--
conclusion
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Quinuprisin/dalfopristin (Synercid) --
modestly
effective for treatment of vancomycin
(Vancocin)-resistant Enterococcus faecium bacteremia-- this
effect may be life-saving
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High incidence of
side effects and adverse drug-drug
interactions suggest
quinuprisin/dalfopristin (Synercid)
should only rarely be used to treat any
other type of infection
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