Nursing pharmacology: Chemotherapy Practice Questions

Less gastrointestinal and renal toxicity:
1. cisplatin (Platinol)
2. carboplatin (Paraplatin)
Side effect(s)-cisplatin (Platinol):
1. nausea, vomiting
2. significant bone marrow effects
3. significant renal dysfunction
4. A & C
5. A, B & C
major acute side effect of cisplatin (Platinol)
1. bone marrow depression
2. renal dysfunction
3. nausea and vomiting
4. acoustic nerve dysfunction
Most important toxic effect associated with alkylating agents:
1. renal dysfunction
2. hepatic failure
3. neurotoxicity
4. bone marrow suppression
5. alopecia
Secondary to bone marrow suppression associate with alkylating agent chemotherapy:
1. septicemia
2. severe infection
3. hemorrhage
4. A & C
5. A, B & C
More likely to cause nausea and vomiting:
1. IV cyclophosphamide (Cytoxan)
2. oral cyclophosphamide (Cytoxan)
3. equally likely
Most antimetabolite anticancer drugs interfere with nucleic acid synthesis or nucleotide synthesis:
1. true
2. false
Methotrexate:
1. tumor resistance associated with decreased polyglutamate formation
2. may be used in treating rheumatoid arthritis
3. induces abortion when combined with a prostaglandin
4. B & C
5. A, B & C
Methotrexate-mechanism action: Folic acid antagonist, acting at dihydrofolate reductase catalytic site:
1. true
2. false
Synergistic with cytarabine (ARA-C) in treating acute adult leukemia:
1. thioguanine
2. mercaptopurine (Purinethol)
Drug resistance-thioguanine
1. decreased HGPRT activity
2. increased alkaline phosphatase which dephosphorylates thiopurine nucleotides
3. both
4. neither
More likely to be associated with drug toxicity when given concurrently with allopurinol (Zyloprim, Purinol)
1. mercaptopurine (Purinethol)
2. thioguanine
In hematologic cancer chemotherapy with purine antagonists, allopurinol (Zyloprim, Purinol) coadministration is used to prevent:
1. cardiotoxicity
2. retroperitoneal fibrosis
3. nephrotoxicity and gout
4. hepatotoxicity
5. depletion of bone calcium
Purine antagonist(s)
1. fludarabine (Fludara)
2. cladribine (Leustatin)
3. pentostatin (Nipent)
4. A & B
5. A, B & C
Pyrimidine antagonists:
1. cytarabine (ARA-C)
2. azatadine (Optimine)
3. fluorouracil (5-FU)
4. B & C
5. A, B & C
Primary mechanism of action: inhibition of topoisomerase II
1. vincristine (Oncovin)
2. teniposide (Vumon)
3. vinblastine (Velban)
4. A & C
5. A, B & C
Clinical use teniposide (Vumon)
1. monocytic leukemia
2. lymphoma
3. testicular cancer
4. oat cell carcinoma
In combination with prednisone (Deltasone): induction of remission in children with acute leukemia
1. vinblastine (Velban)
2. vincristine (Oncovin)
3. both
4. neither
Significant frequency-adverse effect associated with vincristine (Oncovin)
1. bone marrow depression
2. neurotoxicity
3. equal frequency
Used in management of colon: & rectal cancer, including tumors not responding to fluorouracil (5-FU)
1. irinotecan (Camptosar)
2. topotecan (Hycamtin)
Primary adverse effect(s): topotecan (Hycamtin)
1. neutropenia
2. thrombocytopenia
3. anemia
4. A & C
5. A, B & C
Dose-limiting adverse effect for irinotecan (Camptosar):
1. diarrhea
2. nausea
3. vomiting
4. myelosuppression
Clinical uses:taxanes: (paclitaxel (Taxol) & docetaxel (Taxotere))
1. ovarian cancer
2. advanced breast cancer
3. both
4. neither
Taxanes: dose limiting adverse effect(s):
1. peripheral neuropathy
2. thrombocytopenia
3. neutropenia
4. B & C
5. A, B & C
Anticancer antibiotics act by DNA intercalation-blocking DNA & RNA synthesis
1. true
2. false