Nursing pharmacology: Cancer Chemotherapy Drug Practice Questions

Clinical application(s) of alkylating anticancer agents include(s):
1. Suppression of recipient immune responses prior to allogenic transplantation.
2. Treatment of certain autoimmune diseases
3. Both
4. Neither
This alkylating agent toxicity, hemorrhagic cystitis, is most likely to be found with the use of this/these agents.
1. Busulfan
2. Ifosfamide
3. BCNU
4. A & B
5. B & C
6. A & C
7. A, B & C
In hemorrhagic cystitis which may cause significant bladder pathology with hemorrhage, a primary causative toxicant is acrolein.
1. True
2. False
With high cumulative doses, nitrosourea-type alkylating agents are associated with renal toxicity (dose related) that may be sufficiently severe to cause renal failure and death.
1. True
2. False
Which one(s) of the following agents may induce pulmonary fibrosis and interstitial pneumonitis?
1. Busulfan treatment
2. Cyclophosphamide
3. Both
4. Neither
Alkylating agent effect on reproductive tissue: which one(s) of the following statements is/are correct?
1. Alkylating agent administration may deplete testicular germ cells (not Sertoli cells) and result in aspermia
2. Patients achieving remission allowing discontinuation of alkylating agents recover spermatogenic activity (in 2-7 years)
3. Both
4. Neither
Acute myeloid leukemia (preceded by a myelodysplastic phase) may develop as a second cancer in some patients treated with:
1. Chlorambucil
2. Melphalan
3. Both
4. Neither
Which one(s) of the following cancer types have been associated with a delayed leukemogenic effect (a second cancer, acute myeloid leukemia)?
1. Hodgkin lymphoma
2. Multiple myeloma
3. Ovarian carcinoma
4. All of the above
Perhaps 2/3 of individual surviving childhood cancer may display delay drug adverse effects. Example(s) of such complications include/includes:
1. Cardiopulmonary deficit
2. Endocrine dysfunction
3. Renal impairment
4. A & B
5. B & C
6. A & C
7. A, B & C
Streptozotocin (streptozocin) is used for treating both pancreatic metastatic islet cell carcinoma and malignant carcinoid tumors.
1. True
2. False