Nursing pharmacology: Cancer Chemotherapy Drugs: Anti-Metabolites Practice Questions

Trimetrexate (Neutrexin):
1. A relatively lipid-soluble folate antagonist
2. Highly active antitumor activity without requiring leucovorin rescue.
3. Beneficial in treatment of pneumocystis jiroveci (pneumocystis carinae) pneumonia
4. A & B
5. B & C
6. A & C
7. A, B & C
Permetrexed (Alimta):
1. Very well transported into cells
2. Permetrexed is easily converted polyglutamates which inhibit thymidylate synthase, dihydrofolate reductase, and lysine amide ribonucleotide transformylase.
3. Permetrexed exhibits antitumor activity.
4. A & B
5. B & C
6. A & C
7. A, B & C
Permetrexed (Alimta) exhibits activity against which one(s) of the following cancers?
1. Mesothelioma
2. Non-small cell lung adenocarcinomas
3. Ovarian cancer
4. A & B
5. A & C
6. A, B & C
Antimetabolites and main therapeutic uses:
1. Methotrexate: non-Hodgkin's lymphoma; acute lymphoblastic leukemia; breast cancer; bladder cancer; primary CNS lymphoma; osteogenic sarcoma; gestational trophoblastic cancer
2. Pemetrexed: non-small-cell lung cancer, mesothelioma
3. Both
4. Neither
Antimetabolites and main therapeutic uses:
1. Pralatrexate: peripheral T-cell lymphoma
2. Capecitabine: hepatocellular cancer; gastroesophageal cancer; colorectal cancer; pancreatic cancer; breast cancer
3. Both
4. Neither
Which one(s) are primary therapeutic uses of the anticancer, antimetabolite drug 5-fluorouracil?
1. Head and neck cancer
2. Hepatocellular cancer
3. Pancreatic cancer
4. Colorectal cancer
5. Anal cancer
6. Gastroesophageal cancer
7. All of the above
Which one of the following cancers is NOT considered a primary therapeutic use of cytarabine?
1. Non-small-cell lung cancer
2. Acute lymphoblastic leukemia
3. Acute myelogenous leukemia
4. Hodgkin's lymphoma
5. Non-Hodgkin's lymphoma
Which one(s) are primary therapeutic uses of the anticancer, antimetabolite drug Gemcitabine?
1. Pancreatic cancer
2. Non-small-cell lung cancer
3. Breast cancer
4. Bladder cancer
5. Ovarian cancer
6. Hodgkin's lymphoma
7. Soft tissue sarcoma
8. All of the above
Primary therapeutic use(s) of the anticancer, antimetabolite drug 6-mercaptopurine?
1. Acute myeloblastic leukemia
2. Acute lymphoblastic leukemia
3. Both
4. Neither
Primary therapeutic use(s) of the anticancer, antimetabolite drug 6-thioguanine:
1. Acute myelogenous leukemia
2. Acute lymphoblastic leukemia
3. Both
4. Neither