Nursing Pharmacology Chapter 33-34: Cancer Chemotherapy Topoisomerase Inhibitors Practice Questions
Click on the correct answer.
Etoposide (Toposar):
Derivative of podophyllotoxin
IV and oral formulations have been FDA approved for clinical use (USA)
Both
Neither
Dose reduction of etoposide:
In patients with liver dysfunction
In patients with renal dysfunction
Both
Neither
Primary etoposide mechanism of action:
Inhibition of tyrosine transport
Protein kinase inhibition
Topoisomerase II inhibitor
DNA alkylation
Clinical use/uses of etoposide:
Small cell and non-small cell lung cancer
Hodgkin's and non-Hodgkin's lymphoma
Both
Neither
Etoposide may be used in treating gastric cancer.
True
False
Etoposide acute toxicity/toxicities:
Nausea and vomiting
Alopecia
Myelosuppression
A & B
A, B & C
Camptothecins are inhibitors of topoisomerase I enzyme activity.
True
False
Concerning irinotecan adverse effect(s):
Diarrhea occurring within 24 hours
Diarrhea occurring 2-10 days following administration
Both
Neither
Irinotecan is approved as first-line treatment in patients with metastatic colorectal cancer when administered along with 5-fluorouracil (5-FU) and leukovorin.
True
False
Topotecan dosage should be adjusted in patients demonstrating renal impairment..
