Nursing Pharmacology Chapters 33-34: Cancer Chemotherapy Bleomycin

Nursing Pharmacology Practice Questions Chapters 33-34: Cancer Chemotherapy Bleomycin

Which one(s) of the following statement(s) is/are correct?
1. Bleomycin acts by inhibiting RNA polymerase.
2. Bleomycin is categorized as a DNA-cleaving antibiotic.
3. Both
4. Neither
Bleomycin as a drug product consists of a mixture of glycopeptides.
1. True
2. False
Which one(s) of the following statements concerning bleomycin is/are correct?
1. Bleomycin is isolated from Streptomyces verticillus.
2. Normally found chelated with copper (Cu2+), the copper is removed prior to marketing.
3. Both
4. Neither
Clinically used bleomycin is a mixture of two copper-chelating glycopeptides, bleomycins A2 and B2.
1. True
2. False
Bleomycin-associated toxicities overlapped with several other cytotoxic agents associated with various drug classes.
1. True
2. False
Bleomycin application(s):
1. Treatment of Hodgkin disease
2. Treatment of testicular cancer
3. Both
4. Neither
Which one(s) of the following statements concerning bleomycin mechanisms of action is/are correct?
1. Bleomycin induces oxidative damage to nucleotides
2. Bleomycin administration results in both single-and double-stranded DNA breaks.
3. Following bleomycin administration, cells may exhibit chromosomal aberrations such as translocations and chromatid breaks.
4. A & B
5. B & C
6. A & C
7. A & B A & C
Bleomycin's therapeutic activity is terminated by bleomycin hydrolase.
1. True
2. False
Choose (the) correct statement/statements concerning bleomycin.
1. Bleomycin may be administered IV, IM, or subcutaneously
2. Bleomycin readily passes the blood-brain barrier.
3. Most of the drug (about two-thirds) is excreted intact in the urine.
4. A & B
5. B & C
6. A & C
7. A, B & C
Bleomycin doses may have to be reduced in patients with renal impairment.
1. True
2. False
Bleomycin and therapeutic use
1. Bleomycin is an effective drug in treating testicular and ovarian germ cell cancer.
2. Bleomycin is one drug used in a standard curative ABVD treatment regimen for Hodgkin's disease.
3. Both
4. Neither
Bleomycin adverse effect(s):
1. Some myelosuppression
2. Hyperpigmentation
3. Both
4. Neither
Pulmonary toxicity is described as the most serious adverse reactions to bleomycin.
1. True
2. False
Bleomycin toxic reactions may include: hyperthermia, nausea and vomiting, headache, a fulminant reaction (acute) in some patients with lymphoma (mimics anaphylaxis).
1. True
2. False