Antifungal Drugs

Antifungal polyene macrolide that preferentially binds to fungal ergosterol which alters cellular permeability.
1. ketoconazole
2. amphotericin B
3. flucytosine
4. grisefulvin
5. clotrimazole
An azole most commonly used for topical treatment of candidiasis:
1. amphotericin B
2. clotrimazole
3. griseofulvin
4. flucytosine
5. none of the above
Polyene macrolide only used topically, due to systemic toxicity; active against most Candida species--most commonly used for suppression of local candidal infection.
1. miconazole
2. terbinafine
3. nystatin
4. fluconazole
5. flucytosine
Of ketoconazole, itraconazole, and fluconazole--most likely to cause increased arrhythmogenic effects of astemizole or terphidine
1. ketoconazole
2. itraconazole
3. fluconazole
Inhibition of fungal squalene epoxidase is this antifungal drug's mechanism of action:
1. ketoconazole
2. fluconazole
3. terbinafine
4. nystatin
5. A & B
More serious adverse effects: itraconazole (azole) or flucytosine (pyrimidine analogue)
1. flucytosine
2. itraconazole
Most potent of the presently available anti-fungal azoles:
1. fluconazole
2. itraconazole
3. ketoconazole
Azole most likely to get into the cerebral spinal fluid (CSF):
1. ketoconazole
2. itraconazole
3. fluconazole
Given by i.v. administration, the drug of choice for nearly all life-threatening mycotic infections--usually used as the initial induction regimen
1. ketoconazole
2. itraconazole
3. flucytosine
4. amphotericin B
5. nystatin
Topical allylamine(s) used for treating tinea cruris and tinea corporis:
1. terbinafine
2. naftifine
3. both
4. neither