"Acquired infection with Toxoplasma in immunocompetent individuals is generally an asymptomatic infection. 

• However, 10% to 20% of patients with acute infection may develop cervical lymphadenopathy and/or a flu-like illness. 

• The clinical course is benign and self-limited; symptoms usually resolve within a few months to a year.

Immunodeficient patients often have central nervous system (CNS) disease but may have myocarditis, or pneumonitis. 

•  In patients with AIDS, toxoplasmic encephalitis is the most common cause of intracerebral mass lesions and is thought to be due to reactivation of chronic infection. 

•  Toxoplasmosis in patients being treated with immunosuppressive drugs may be due to either newly acquired or reactivated latent infection.

Congenital toxoplasmosis results from an acute primary infection acquired by the mother during pregnancy. 

• The incidence and severity of congenital toxoplasmosis vary with the trimester during which infection was acquired. 

• Because treatment of the mother reduces the incidence of congenital infection, prompt and accurate diagnosis is extremely important. 

• Most infants with subclinical infection at birth will subsequently develop signs or symptoms of congenital toxoplasmosis unless the infection is treated.

 Ocular Toxoplasma infection, an important cause of chorioretinitis in the United States, is usually a result of congenital infection.  Patients are often asymptomatic until the second or third decade of life, when lesions develop in the eye." source: CDC-public domain