Nursing Pharmacology: Antiviral Drugs

Non-Nucleoside Reverse Transcriptase Inhibitors⁷
Delavirdine (Rescriptor)
Adverse Effects:⁷ Elevated liver enzymes, rash, headache, nausea, diarrhea Miscellaneous:⁷ Numerous contraindicated medications, consult reference 7, drug package insert or other authoritative sources for details. Should not be administered with rifabutin (Mycobutin, antituberculosis bactericidal antibiotic agent) or fosamprenavir
Efavirenz (Sustiva)
Adverse Effects:⁷ CNS effects, elevation of liver enzymes, nausea, headache Miscellaneous:⁷ Numerous contraindicated medications, consult reference 7, drug package insert or other authoritative sources for details.
Etravirine (Intelence)
Adverse Effects:⁷ Nausea, diarrhea, rash Miscellaneous⁷ : Numerous contraindicated medications, consult reference 7, drug package insert or other authoritative sources for details. Should not be adminstered with other non-nucleoside reverse transcriptase inhibitors, or with: Indinavir Atazanavir-ritonavir Fosamprenavir-ritonavir Tipranavir-ritonavir or any "unboosted" protease inhibitor
Nevirapine (Viramune)
Adverse Effects:⁷ Hepatitis, rash, headache, nausea Miscellaneous:⁷ Numerous contraindicated medications, consult reference 7, drug package insert or other authoritative sources for details. Should not be given with atazanavir
Rilpivirine (Endurant)
Adverse Effects:⁷ Elevated liver enzymes, rash, insomnia, depression Miscellaneous:⁷ Numerous contraindicated medications, consult reference 7, drug package insert or other authoritative sources for details.

References
Flexner C Antiretroviral Agents and Treatment of HIV Infection, Chapter 59 in Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th edition (Brunton LL Chabner BA Knollmann BC, eds; Brunton LL, ed; Blumenthal DK Murri N Hilal-Dandan R, assoc eds, Knollmann BC, consulting ed, on-line edition) The McGraw-Hill Companies, 2011. Fauci AS Lane HC Chapter 189, Human Immunodeficiency Virus Disease: AIDS and Related Disorders, in Harrison's Online (Dan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, J. Larry Jameson, Joseph Loscalzo, Eds.), Harrison's Principles of Internal Medicine, 18th edition, The McGraw-Hill Companies, Inc. 2012. Longo DL Fauci AS 188, The Human Retroviruses, in Harrison's Online (Dan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, J. Larry Jameson, Joseph Loscalzo, Eds.), Harrison's Principles of Internal Medicine, 18th edition, The McGraw-Hill Companies, Inc. 2012. Woster PM Chapter 43: Antiviral Agents and Protease Inhibitors in Foye's Principles of Medicinal Chemistry 6e, Lemke, TL Williams DA, eds; Roche VG Zito SW, asst eds) Wolters Kluwer\|Lippincott Williams & Wilkins 1214, 2008. HIV Overview: The HIV Life Cycle, Education Materials, AIDSinfo, NIH http://aidsinfo.nih.gov/education-materials/fact-sheets/19/73/the-hiv-life-cycle Tsibris AMN Hirsch MS Chapter 130 Antiretroviral Therapy for Human Immunodeficiency Virus Infection in Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 8e (Bennett JE Bolin R Blaser, eds) Elsevier, Inc/Saunders 2015, online version. Safrin S Chapter 49: Antiviral Agents: Antiretroviral Agents in Basic & Clinical Pharmacology 13e (Katzung BG Trevor AJ, eds) 2015, online edition.

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