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Receptor Classification

 

 

Catecholamine Refractoriness

Lefkowitz, R.J, Hoffman, B.B and Taylor, P. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems, In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics,(Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) TheMcGraw-Hill Companies, Inc.,1996, pp.112-137.

 

Metabolic Transformation

Pulmonary Uptake

 

 

 

Clinical Use: Sympathomimetic Agents: Brief Summary 

 

α Adrenergic Agonists

 

 

Non-selective Adrenergic agonists

1-adrenergic receptor selective agonists

2-selective agonists (various drugs)

Overview-- Varied Clinical Uses of Adrenergic Drugs

 Drugs Used in Treating Shock

Dopamine and Dobutamine

Dobutamine

Dopamine (Intropin)

Therapeutic Uses for Dopamine & Dobutamine: Summary

 

 

Drugs in Cardiogenic Shock: Nitrates, Adrenergic Agonists, Amrinone (Inocor) and Milrinone (Primacor)

 

 

 

 

 

  Antihypertensive Effects of some adrenergic receptor agonists

Adrenergic Agonists in Treating some Cardiac Arrhythmias

Vascular Effects: α Adrenergic Agonists

Congestive Heart Failure

Asthma  

Nasal Decongestion

Allergic Reactions

 

Hollenberg, S.M. and Parrillo, J.E., Shock, In Harrison's Principles of Internal Medicine 14th edition, (Isselbacher, K.J., Braunwald, E., Wilson, J.D., Martin, J.B., Fauci, A.S. and Kasper, D.L., eds) McGraw-Hill, Inc (Health Professions Division), 1998, p. 215-222

Hoffman, B.B and Lefkowitz, R.J, Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists, In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics, (Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) TheMcGraw-Hill Companies, Inc.,1996, pp.222-224.

Stoelting, R.K., "Sympathomimetics", in Pharmacology and Physiology in Anesthetic Practice, Lippincott-Raven Publishers, 1999, p.259.

 

 

Therapeutic uses of indirect-acting adrenoceptor agonists

 

Ephedrine

 

Mephentermine (Wyamine)

 

Metaraminol (Aramine)

Stoelting, R.K., "Sympathomimetics", in Pharmacology and Physiology in Anesthetic Practice, Lippincott-Raven Publishers, 1999, pp. 271-272

 

 

Adverse Effects: β-Adrenoceptor Antagonists

 

α-Adrenergic Antagonists (Blockers)

  Introduction

 

α1-adrenergic receptor antagonists- Cardiovascular Effects

 

α2-adrenergic receptor antagonists

 

 

Phenoxybenzamine (Dibenzyline)

 Therapeutic Uses for α-adrenergic blocking drugs

 

 

Phentolamine  (Regitine) and Tolazoline (Priscoline)

Prazosin (Minipress) and Terazosin (Hytrin)

 

 

Other alpha adrenergic receptor blockers

Hoffman, B.B and Lefkowitz, R.J, Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists, In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics, (Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) TheMcGraw-Hill Companies, Inc.,1996, pp.225-232.

 

 

 

 

 

-Adrenergic Antagonists

 

Introduction

 

 

Nonselective- adrenergic receptor antagonists

 

Selective-1 adrenergic receptor antagonists

 

Adverse Effects of adrenergic receptor antagonists

  Therapeutic Uses for β-adrenergic receptor antagonists (Blockers)

Hoffman, B.B and Lefkowitz, R.J, Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists, In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics, (Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) The McGraw-Hill Companies, Inc.,1996, pp.232-242.

Stoelting, R.K., "Sympathomimetics", in Pharmacology and Physiology in Anesthetic Practice, Lippincott-Raven Publishers, 1999, pp. 293-301

 

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