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Nursing Pharmacology:  Autonomic Pharmacology Adrenergic Drugs

 

 

Drug Lists

 

Catecholamines

Drug

Receptors

Epinephrine

α1, α2 1, 2

Norepinephrine (Levophed)

α1, α2, 1

Isoproterenol (Isuprel)

1, 2

Dobutamine (Dobutrex)

11)

Dopamine (Intropin)

D-1 (α1 and 1 at high doses)

 

Direct adrenoceptor agonists

Drug

Receptor Selectivity

Phenylephrine (Neo-Synephrine)

α1

Methoxamine (Vasoxyl)

α1

Oxymetazoline (Afrin)

α1, α2

Clonidine (Catapres)

α2

Ritodrine (Yutopar)

2

Terbutaline (Brethine)

2

Albuterol (Ventolin,Proventil)

2

Salmeterol (Serevent)

2

 

Indirect sympathomimetics

  • Ephedrine, Pseudoephedrine

  • Cocaine

  • Tyramine

  • Amphetamine

  • Release & direct receptor activation

  • Uptake I inhibitor

  • Release

  • see ephedrine, but greater CNS actions

 

α-Adrenoceptor antagonists

Drug

Receptor Selectivity (α1 vs.α2)

Prazosin (Minipress)

α1

Terazosin (Hytrin)

α1

Trimazosin

α1

Doxazosin (Cardura)

α1

Phentolamine (Regitine)

Non-selective

Phenoxybenzamine (Dibenzyline)

Only slightly selective for α1 (non-competitive)

Tolazoline (Priscoline)

Non-selective

Labetalol (Trandate, Normodyne)

α1 (also non-selective β-antagonist)

Yohimbine (Yocon)

α2

 

-Adrenoceptor antagonists

Drug

Receptor Selectivity (1 vs. 2)

Propranolol (Inderal)

non-selective

Metoprolol (Lopressor)

1

Esmolol (Brevibloc)

1

Atenolol (Tenormin)

1

Nadolol (Corgard)

Non-selective

Timolol (Blocadren)

Non-selective

Pindolol (Visken)

Non-selective (partial agonist)

Labetalol (Trandate, Normodyne)

Non-selective (selective a1-antagonist)

 

Adrenergic Neuron Blocking Drugs

  • Reserpine:  non-selective blockade of vesicular uptake and storage of biogenic amines.

  • Guanethidine (Ismelin):  similar to reserpine

 

 

 

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