Drug

Receptors

Epinephrine

α₁, α₂ ß₁, ß₂

Norepinephrine (Levophed)

α₁, α₂, ß₁

Isoproterenol (Isuprel)

ß₁, ß₂

Dobutamine (Dobutrex)

ß₁ (α₁)

Dopamine (Intropin)

D-1 (α₁ and ß₁ at high doses)

Drug

Receptor Selectivity

Phenylephrine (Neo-Synephrine)

α₁

Methoxamine (Vasoxyl)

α₁

Oxymetazoline (Afrin)

α₁, α₂

Clonidine (Catapres)

α₂

Ritodrine (Yutopar)

ß₂

Terbutaline (Brethine)

ß₂

Albuterol (Ventolin,Proventil)

ß₂

Salmeterol (Serevent)

ß₂

Drug

Receptor Selectivity (α₁ vs.α₂)

Prazosin (Minipress)

α₁

Terazosin (Hytrin)

α₁

Trimazosin

α₁

Doxazosin (Cardura)

α₁

Phentolamine (Regitine)

Non-selective

Phenoxybenzamine (Dibenzyline)

Only slightly selective for α₁ (non-competitive)

Tolazoline (Priscoline)

Non-selective

Labetalol (Trandate, Normodyne)

α₁ (also non-selective β-antagonist)

Yohimbine (Yocon)

α₂

Drug

Receptor Selectivity (ß₁ vs. ß₂)

Propranolol (Inderal)

non-selective

Metoprolol (Lopressor)

ß₁

Esmolol (Brevibloc)

ß₁

Atenolol (Tenormin)

ß₁

Nadolol (Corgard)

Non-selective

Timolol (Blocadren)

Non-selective

Pindolol (Visken)

Non-selective (partial agonist)

Labetalol (Trandate, Normodyne)

Non-selective (selective a₁-antagonist)

• Reserpine:  non-selective blockade of vesicular uptake and storage of biogenic amines.

• Guanethidine (Ismelin):  similar to reserpine