page back page forward

Section Table of Contents

Return to Nursing Pharmacology Table of Contents

Nursing Pharmacology  Autonomic Pharmacology Adrenergic Drugs 

 

Norepinephrine (Levophed)

Blood Pressure

Blood Pressure Effects

Epinephrine

Norepinephrine

Systolic

Mean Pressure

Diastolic

variable

Mean Pulmonary

Adaptation of Table 10-2 from: Hoffman, B.B and Lefkowitz, R.J, Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists, In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics,(Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) The McGraw-Hill Companies, Inc.,1996, pp.199-242

 

                Norepinephrine Effects on Vascular Tone of Arterioles  (Sympathetic Nervous System Effects)          
Coronary α1,2; β2 constriction; dilatation

Skin/Mucosa

α1,2

constriction

Skeletal Muscle

α; β2

constriction; dilatation

Cerebral

α

slight constriction

Pulmonary

α1 , β2

constriction; dilatation

Abdominal viscera

α1, β2

constriction; dilatation

Salivary glands

α1,2

constriction

Renal

α1,21,2

constriction; dilatation

Based on Table 6-1: Lefkowitz, R.J, Hoffman, B.B and Taylor, P. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems, In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics,( Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) The McGraw-Hill Companies, Inc.,1996, pp.110-111.

 

Vascular Effects

Peripheral Circulation

Peripheral Circulation

Epinephrine

Norepinephrine

Total Peripheral Resistance

Cerebral Blood Flow

no effect or decrease

Muscle Blood Flow

no effect or decrease

Cutaneous Blood Flow

Renal Blood Flow

Splanchnic Blood Flow

no effect or increase

increase, decrease

0.1-0.4 ug/kg/min IV infusion

Adaptation of Table 10-2 from: Hoffman, B.B and Lefkowitz, R.J, Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists, In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics, Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) The McGraw-Hill Companies, Inc.,1996, pp.199-242

Hoffman, B.B and Lefkowitz, R.J, Catecholamines, Sympathomimetic Drugs, and Adrenergic Receptor Antagonists, In, Goodman and Gillman's The Pharmacologial Basis of Therapeutics, (Hardman, J.G, Limbird, L.E, Molinoff, P.B., Ruddon, R.W, and Gilman, A.G.,eds) TheMcGraw-Hill Companies, Inc.,1996, pp.204-213.

 

 

 

page back page forward

Section Table of Contents

Return to Nursing Pharmacology Table of Contents