-
Analog of lidocaine, but with reduced first-pass
metabolism.
-
Used for
treatment of ventricular arrhythmias
-
Suitable
for oral administration, but RARELY USED due to
possibly fatal bone marrow aplasia and pulmonary
fibrosis.
-
Similar
electrophysiologically to lidocaine
-
Tremor and
nausea are major dose-related adverse side
effects
-
Excreted
by the kidney, accordingly dose should be reduced
in patients with renal disease.
-
Combination
with quinidine may increase efficacy and diminish
adverse effects.
|
