Adenosine [ah den' o seen]
  • Effects mediated through G protein-coupled adenosine receptor.

  • Activates acetylcholine-sensitive K+ current in the atrium and sinus and A-V node.

  • Decreases action potential duration

  • Reduces automaticity

  • Increases A-V nodal refractoriness

  • Rapidly terminates re-entrant supraventricular arrhythmias

page back