-
Used in patients with ventricular
tachycardia or fibrillation resistant to
treatment with other drugs.
-
Effective inhibitor of abnormal automaticity.
-
Blocks sodium and potassium channels and prolongs
action potential duration.
-
Most serious adverse effect seen in
long-term therapy is a rapidly progressive
pulmonary fibrosis which may be fatal
-
Potent inhibitor of hepatic metabolism or
renal elimination of many drugs.
-
Warfarin, quinidine, procainamide and
digoxin are examples of drugs which may require
dosage reduction during amiodarone administration.
|