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Amrinone [am' ri none]
Milrinone [mil' ri none]
  • Amrinone and milrinone are bipyridine derivatives that are relatively selective inhibitors of cGMP-inhbited, cyclic AMP phosphodiesterase (type III).

  • These agents cause vasodilation (decreased afterload) and increase myocardial contractility.

  • Milrinone is the agent of choice among the phosphodiesterase inhibitors for short-term parenteral support in severe heart failure patients. Oral formulations are not used due to intolerable side-effects including increases in mortality.

Adverse Effects
  • Amrinone has been associated with a reversible thrombocytopenia.