Clonidine acts in the brain, inhibiting
adrenergic outflow from the brainstem.
of sympathetic outflow results in a decrease in
reduces cardiac output:
Clonidine does not interfere with cardiovascular
responses to exercise.
Renal blood flow and function is
maintained during clonidine treatment.
Clonidine has minimal or no effect on plasma
Dry Mouth (xerostomia)
Bradycardia (in patients with SA nodal
Withdrawal syndrome upon abrupt
discontinuation (increased blood pressure,
headache, tachycardia, apprehension, tremors)