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Diltiazem [dil tye' a zem]
(Class IV, Calcium Channel Blocker)
  • Blocks cardiac calcium channels in slow response tissues, such as the sinus and AV nodes.

  • Useful in treating AV reentrant tachyarrhythmias and in management of high ventricular rates secondary to atrial flutter or fibrillation.

  • Major adverse effect (i.v. administration) is hypotension.

  • Heart block or sinus bradycardia can also occur.