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Labetalol (α1 and β Adrenoceptor Antagonist
la bet' a lol]
  • Labetalol is a competitive antagonist at both alpha1 and beta1-adrenergic receptors. It also has an intrinsic sympathomimetic effect at beta2 receptors

  • Antihypertensive effects of labetalol results from actions at both alpha1 and beta-adrenergic receptors. Alpha1 receptor blockade results in vasodilatation which is further enhanced by beta2 receptor activation. A reduction in heart rate is mediated by beta-1 receptor antagonism.

  • Labetalol does not alter serum lipids.

  • Adverse Effects:

    • Orthostatic hypotension may occur due to alpha1 receptor blockade.

    • Liver injury has been reported with labetalol usage.