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Mexiletine[mex il' e teen]
(Class I, Sodium Channel Blocker)
  • Analog of lidocaine, but with reduced first-pass metabolism.

  • Used for treatment of ventricular arrhythmias.

  • Suitable for oral administration.

  • Similar electrophysiologically to lidocaine.

  • Tremor and nausea are major dose-related adverse side effects.

  •  Metabolized by the liver.

  •  Combination with quinidine may increase efficacy and diminish adverse effects.