channel blockers are effective in
treating hypertension because they reduce
Arteriolar vascular tone depends on free
concentration. Calcium channel blockers reduce
transmembrane movement of Ca2+
, reduce the amount reaching intracellular sites
and therefore reduce vascular smooth muscle tone.
All calcium channel blocks appear
similarly effective for management of mild to
For low-renin hypertensive patients
(elderly and African-American groups), Ca2+
channel blockers appear good choices for
monotherapy (single drug) control.
Nisoldipine, a dihydropyridine, is
similar to nifedipine but five to ten times more
potent as a vasodilator and little effect on
Nisoldipine is available as a long-acting
extended release preparation and appears
effective in treating mild to moderate
Dizziness, headache and peripheral edema.
Concurrent use of cimetadine, a fatty
meal, or grapefruit juice may increase serum
concentations and increase toxicity.